Host-microbe interactions

Immunology Meets Philosophy vol. 2

15-16 September 2025
Faculty of Science, Charles University, Viničná 7, Prague

This event features experts working on a range of phenomena related to the diverse host-microbe interactions, from infectious diseases to microbiota, with a wide array of perspectives, including evolutionary and metabolic ones.

Confirmed speakers

Janelle Ayres
Professor at the Salk Institute for Biological Studies
How a host responds to a pathogen determines outcome of infection, and the long-standing belief was that a host needed to kill an invading pathogen in order to survive. Prof. Ayres’ discovery of the host “co-operative defense” system has challenged this notion. As part of her paradigm-shifting work, Ayres showed that a host can employ disease tolerance defenses executed by the co-operative defense system during infection that limits pathology and promotes host survival while having no effect on the pathogen. Ayres made a number of other breakthroughs in this area, revealing not only more about fundamental, dynamic biological processes but also charting discoveries that have potential translational applications for treating a wide array of diseases as well as ways to promote healthy aging.

David Schneider
Professor of Microbiology and Immunology at Stanford University
Prof. Schneider’s research focuses on innate immunity and microbial pathogenesis, particularly how organisms recover from infections. His team studies bacterial, fungal, viral, and malaria infections using innovative methods like phase plots to predict infection outcomes and guide treatments. They prioritize whole-animal health assessments over in vitro studies, employing genetics, microarrays, and flow cytometry. Their work spans two key models: a mouse model for malaria, where they map disease progression to identify recovery mechanisms, and fruit flies, leveraging Drosophila’s genetic tools to uncover insights into infection dynamics.

Tracy Hussell
Professor of Inflammatory Disease & Director of the Lydia Becker Institute of Immunology and Inflammation
Prof. Hussell’s research focus is on studying the long-term impact of infections on the lung and how cell crosstalk can go wrong. She is now working on an idea that immune cells are not to blame in inflammation, it is just that they are given the wrong cues. Prof. Hussell also currently serves as the elected president of the British Society for Immunology.

Tamar Schneider
Open University of Israel
Dr. Tamar Schneider is a philosopher of science working on the notion of individuality in relation to its close and intimate microbial milieu, as they appear in ecology, evolution, and medicine. Her work is guided by the heuristics of mutuality of interactions and its unique role in constructing knowledge of systems and processes in biology.

Peter Šebo
Professor at the Institute of Microbiology of the Czech Academy of Sciences
Prof. Šebo is the head of Laboratory of Molecular Biology of Bacterial Pathogens where he studies the tricks and tools used by pathogenic bacteria to suppress our immune defense. In particular, his group studies among other the emerging pediatric pathogen Kingella kingeae and the major focus is on the whooping cough agent Bordetella pertussis that causes the respiratory illness called pertussis. This infectious disease can be fatal to smallest non-vaccinated infants and is currently on the rise in the most developed and wealthiest countries (where vaccine refusal is on the rise and less reactogenic but also less efficacious pertussis vaccines are used).

 

Dagmar Šrůtková
Institute of Microbiology of the Czech Academy of Sciences
Dr. Dagmar Šrůtková is a researcher at the group of Integrative Physiology of Gnotobionts uses the germ-free mouse model to study the microbiota, specific bacterial strains and bacterial antigenic components impact on the physiological status of the eukaryotic host in two main research lines 1) host juvenile growth and 2) prevention/therapy of allergic sensitization and allergy development.

Martin Zach
Institute of Philosophy of the Czech Academy of Sciences
Dr. Zach’s research interests concern the concept of disease tolerance, and the interactions between the immune system and other physiological systems.

More speakers will be confirmed in due time.